Possible Interaction: Adenosine Triphosphate and Iron, Dietary

“Addition of iron further decreased both GSH and ATP and a potentiative interaction between ufCB and FeSO(4) was observed, but only at the highest iron concentrations tested.”

“In iron overload the liver ATP resonances were broadened.”

“Deterioration of mitochondrial function in the presence of iron was demonstrated by low RCR (46% decrease) and low ATP content (96% decrease).”

“In vitro and in vivo, mouse tissues assayed for 45Ca2+ uptake have shown that ATP increases the Ca2+ take-up in the presence of lactates of iron and aluminum, but this effect is absent with the citrates.”

“The results obtained suggested that iron loading might induce significant decrease in hepatic and splenic ATP levels via malfunction of their mitochondria and might lead dissociation of RNase-RNase inhibitor complex to activate 3'-AMP forming enzyme in both tissues.”

“Surprisingly the serum factor required for myeloid cell survival was identified as iron, and loss of iron led to marked reductions in ATP production.”

“Although NO could reduce Fe uptake by a number of mechanisms, the decrease in ATP levels appears, at least in part, to play a role.”

“ ATP seems to play a key role in an iron translocation that enhances the effects of the iron complexes.”

“There was a highly significant correlation between the rate of iron uptake into cytosolic and stromal fractions of the cells and ATP levels.”

“The effect of added ATP was at least 2-fold, i.e. that of providing energy and that of chelating iron.”

“When the mitochondria respired on endogenous substrate, the energy-dependent accumulation of iron increased at low concentrations of ATP , whereas higher concentrations (greater than 50 mu M) gradually inhibited the uptake.”