Possible Interaction: Adenosine Triphosphate and Iodides

“ATP concentration-response comparisons revealed that substitution of chloride by glutamate decreased agonist efficacy, while substitution by iodide increased agonist efficacy at high ATP concentrations.”

“ ATP induced a transient loss of iodide from FRTL-5 cells that was dependent on the mobilization of intracellular calcium, and was inhibited by CaCC/ANO1 inhibitors and siRNA against ANO1.”

“The allosteric inhibitor, ATP , increased both the accessibility of PLP to iodide and the quantum yield, suggesting induction of a different conformational state which we term I, evidence for which has also been presented by other groups using other probes.”

“The presence of ATP lowers the concentration of I- required for 50% inhibition from 350 mM to 100 mM and increases the maximal inhibition observed in the presence of NO3- from 65% to 100%.”

“ ATP added to F1 previously depleted of loosely bound nucleotides changes the quenching constant of iodide and the quantum yield and this is interpreted to be due to a conformational change induced by the binding of the nucleotide to the enzyme.”

“A significant decrease in thyroidal ATP occurred as early as 5 min and lasted at least 60 min after injection of 250 μg of iodide.”

“Steady-state quenching studies with iodide indicate that addition of ATP results in a 3.0-3.5-fold decrease in the apparent Stern-Volmer quenching constants for the wild-type and W158S enzymes.”