Possible Interaction: Adenosine Triphosphate and Inosine

“Adenosine and inosine inhibited platelet aggregation and ATP release stimulated by ADP and collagen.”

“Catabolism … adenosine triphosphate proceeded far beyond the level of the nucleotides (63% +/- 17% of … total sum of purines), resulting in an accumulation of adenosine and inosine (5% +/- 4% and 30% +/- 13% of the total sum of purines) and even of hypoxanthine (1% +/- 1% of the total sum of purines).”

“The inosine increased the ATP level and markedly enhanced the lymphocyte blast-formation and proliferation of the fibroblastic cells and leukemic cell-lines.”

“Bilirubin-induced haemolysis could be reduced after increasing the ATP levels by incubation of the red cells with inosine.”

“Additionally, both the reduction in intracellular ATP and the effects on insulin action caused by glucosamine could be prevented by the addition of inosine , which served as an alternative energy source in the medium.”

“After 4 hour reperfusion with inosine, ATP levels increased to 95.5% of preischemic value (30 minute ischemia) and 76.2% (60 minute ischemia).”

“However during IS, pretreatment with IN minimized ATP loss for the first 20 min relative to untreated controls (UNT, P less than 0.05).”

“If the cells were exposed to prolonged anaerobic incubation, addition of glutamine and inosine markedly increased O2 uptake and [ ATP ], suggesting the crucial importance of aspartate production by glutamine oxidation for the recovery of energy metabolism in the cells.”

“The postjunctional contractile effect elicited by ADP and ATP was enhanced by pretreatment with inosine nucleotides, alpha, beta-meADP or TDP, indicating decreased inactivation of ADP and ATP during concurrent nucleotide administration.”

“Inclusion of inosine in the CPS reduced the degradation of ATP and TAN and improved functional recovery.”