Possible Interaction: Adenosine Triphosphate and Glycine

“However, in a number of cases, introduction of a glycine or alanine gatekeeper results in diminished kinase activity and ATP affinity.”

“ Glycine , an active‐site ligand, increased the serine racemase affinity for ATP by ~ 22‐fold, abolishing cooperativity.”

“ ATP is predicted to form hydrogen bond interactions with residues Gly 81, Thr 82, Asn 83, Arg 85, Lys 169, Thr 228, Lys 296, Thr 332, and Ser 336.”

“In addition, mitochondrial ΔΨm and ATP concentration were increased in 6 mM glycine group compared with the control group.”

“Using whole-cell patch-clamp techniques in rat retinal slice preparations, we demonstrated that ATP suppressed glycine receptor-mediated currents of OFF type ganglion cells (OFF-GCs) dose-dependently, and the effect was in part mediated by P2Y1 and P2Y11, but not by P2X.”

“We found that millimolar concentrations of glycine enhance microglial intracellular calcium transients induced by 100 μM ATP or by 500 nM thapsigargin.”

“ Glycine treatment also induced a 11% increase of hepatocyte volume and transient ATP release.”

“6 These results suggest that ATP enhances glycine release from nerve terminals, presumably resulting in the inhibition of SG neurons which conduct nociceptive signals to the CNS.”

“These complex, differential effects on nucleotide binding indicate that the glycines influence the relative affinities of ADP and ATP.”

“Meanwhile, it has been reported that ATP stimulates the release of glycine , an inhibitory neurotransmitter from interneurons of dorsal horn.”