Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Adenosine Triphosphate and Glutathione

Research Papers that Mention the Interaction

Supplementation of GSHE and DPD prevented the RBV‐induced decrease in osmotic resistance, adenosyl triphosphate ( ATP ), and 2,3‐diphosphoglycerate (DPG), the loss of glutathione and protein sulfhydrils, and the formation of thiobarbituric acid reactive substances (TBARs).
Hepatology  •  2004  |  View Paper
In contrast, oxidized glutathione (GSSG) stimulates ATP hydrolysis without affecting ATP binding, whereas reduced glutathione GSH ) inhibits ATP binding and hydrolysis.
PloS one  •  2015  |  View Paper
On the other hand, GSH binding induces a conformational change that affects the structural organization of the cytosolic domains and enhances ATP binding and/or hydrolysis suggesting that GSH-mediated conformational changes are required for the coupling between drug transport and ATP hydrolysis.
The Journal of Biological Chemistry  •  2003  |  View Paper
Using a variety of techniques, we show here that glutathione promoters activate a Ca2+ flux and decrease ATP levels in Infected human fibroblasts.
Experimental biology and medicine  •  2001  |  View Paper
ATP and adenosine contribute to normoxic stabilization of HIF-1 and, with GSH , inhibit the NF-kappa B pathway that is involved in the suppression of erythroid-specific genes.
Artificial organs  •  2012  |  View Paper
ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels.
Chemotherapy  •  2010  |  View Paper
Verapamil enhanced GSH efflux, whereas ATP decreased GSH efflux.
Life sciences  •  1992  |  View Paper
The failure of ATP to reverse mitochondrial swelling induced by glutathione appeared to be a significant exception, since swelling of this type is more drastic and apparently diierent in kind from that produced by the other agents listed (4, 11).
The Journal of biological chemistry  •  1962  |  View Paper
A significant correlation was found between GSH and ATP across all groups at 7 days treatment.
International journal of experimental pathology  •  2014  |  View Paper
Furthermore, we found that the low levels of ATP attenuated the synthesis of glutathione , leading to the decrease of CY detoxification, thus increasing the sensitivity of Treg cells to low-dose CY.
Cancer research  •  2010  |  View Paper
Show More