PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence

 induced cell growth inhibition, increased reactive oxygen species and decreased 

Kinetic analysis of cellular nucleotides correlated to growth and tPA production in perfusion cultures of human fibroblast cells

 consumption, with a lower correlation to oxygen utilization.

Glutamine protects mitochondrial structure and function in oxygen toxicity.

 significantly increased cellular ATP levels in normoxia and prevented the loss of 

 in hyperoxia seen in glutamine-deprived cells.

Influence of glutamine on the phenotype and function of human monocytes.

 was associated with a significant reduction in cellular adenosine triphosphate (

), which may have influenced cell surface marker expression and phagocytosis.

H2S stimulated bioenergetics in chicken erythrocytes and the underlying mechanism.

Glutamine Reduces the Apoptosis of H9C2 Cells Treated with High-Glucose and Reperfusion through an Oxidation-Related Mechanism

 supplementation prevented from mitochondrial dysfunction presented as mitochondrial membrane potential and 

 levels and attenuated cytochrome c release into the cytosol and caspase-3 activation.

Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70.

 to adenosine diphosphate in the lung after LPS.

The effect of adenine nucleotides on the rate and fate of glutamine utilization by incubated mitochondria isolated from rat mesenteric lymph nodes

Cellular energetics in hemorrhagic shock: restoring adenosine triphosphate to the cells.

BACKGROUND This is a review of studies with two agents,

 and crocetin, which have been found to enhance recovery of 

 (ATP) and adenosine diphosphate after hemorrhagic shock.

Phe(475) and Glu(446) but not Ser(445) participate in ATP-binding to the alpha-subunit of Na(+)/K(+)-ATPase.

Replacement of Phe(475) with Trp and Glu(446) with

, whereas the substitution of Ser(445) with Ala did not affect ATP binding.

Bidirectional supply of glutamine maintains enterocyte ATP content in the in vitro Ussing chamber model

 to both sides of the stripped mucosa improved 

 levels compared to the Krebs solution (P<0.05), and the addition of glutamine resulted in an increase in short circuit current (P<0.05).

ATP converts necrosis to apoptosis in oxidant-injured endothelial cells.

 levels in oxidant-stressed cells may be potent means of shifting cell death during inflammation to the noninflammatory form of death--apoptosis.

Glucose and glutamine provide similar proportions of energy to mucosal cells of rat small intestine.

 production from exogenous substrates was higher when both glucose and 

 were present simultaneously than when either substrate was present alone, and glucose was calculated to provide 50-60% of the net ATP produced from these two substrates.

Orientation changes in myosin regulatory light chains following photorelease of ATP in skinned muscle fibers.

 and tension transients slowed when liberated 

Glutamine and glucose metabolism in enterocytes of the neonatal pig.

 contributed approximately 2-fold greater amounts of 

 to 0- to 7-day-old pig enterocytes than glucose.(ABSTRACT TRUNCATED AT 250 WORDS)

Influence of stage of lactation on glucose and glutamine metabolism in isolated enterocytes from dairy cattle.

In enterocytes from all cows, the rate of

 (ATP) production was greater in the presence of both glucose and 

 compared with that in the presence of either substrate alone.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia.

Cerebral glutamate concentrations were increased only in spf mice treated with sodium benzoate, whereas ATP and acetyl CoA were decreased (P < 0.001), in both normal and affected mice, indicating that

Nucleosides and glutamine are primary energy substrates for embryonic and adult chicken red cells.

Of seven potential citric acid cycle substrates, only

Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase.

 ([ATP] approximately 100% at 10 mmol/L) and citrate (approximately 30% at 10 mmol/L), but it was unaffected by malate, 2-oxoglutarate, lactate, and ammonia.

Mechanism of protection of oxidant-injured endothelial cells by glutamine.

 supplementation before oxidant exposure has recently been shown to significantly enhance 

 (ATP) levels and viability in endothelial cells.

Significant improvement of endothelial cell

 levels and short-term viability was seen with addition of 

 as late as 15 minutes after addition of H2O2.

Protective effect of glutamine on endothelial cell ATP in oxidant injury.

 as low as 50 microM produced significant improvement of 

 levels in endothelial cells exposed to 5 mM H2O2.

 during H2O2 injury significantly enhanced 

Glucose, glutamine and ketone body utilisation by resting and concanavalin A activated rat splenic lymphocytes.

 metabolism makes only a minor contribution to lymphocyte 

Interaction of metabolism of aspartate and inosine and energy state of malignant cells.

If the cells were exposed to prolonged anaerobic incubation, addition of

 and inosine markedly increased O2 uptake and [

], suggesting the crucial importance of aspartate production by glutamine oxidation for the recovery of energy metabolism in the cells.

ATP turnover and renal response of dog tubules to pH changes in vitro.

Gluconeogenesis from lactate is minimally influenced by incubation pH. It is concluded that the

 by proximal tubules in vitro as in vivo in the dog, and that the response to acidification is small in vitro because of the absence of alternative substrates.

Evidence for metabolic regulation of pancreatic glucagon secretion by L-glutamine.

 to about 60 per cent in A-cell rich islets, but not significantly changed in normal islets.

Kinetic mechanism of beef pancreatic L-asparagine synthetase.

 sequentially bind, followed by the release of glutamate and the addition of aspartate.

Properties of an ATP-binding protein isolated from membranes of nerve endings.

From pH and other studies it appears that the

 is electrostatically bound to the amino groups of such amino acids as 

Total Cellular ATP Production Changes With Primary Substrate in MCF7 Breast Cancer Cells

Here, we show that MCF7 breast cancer cells, given different combinations of the common cell culture substrates glucose,

 production rates 1.6-fold higher than when cells are limited to each individual substrate.

Effects of glutamine on intestinal mucus barrier after burn injury.

Additional experiments showed that supplementation with

 could markedly raise the content of glutamine, glutathione (GSH), and 

Escherichia coli glutaminyl-tRNA synthetase is electrostatically optimized for binding of its cognate substrates.

, two of the natural ligands, were found to be extremely complementary to their binding sites, particularly in regions seen to make electrostatic interactions in the structure.

Light-dependent synthesis of glutamine in pea-chloroplast preparations

Synchronization of the three reaction centers within carbamoyl phosphate synthetase.

 by a factor of 275, but there was no effect by glutamine on the initial phosphorylation of bicarbonate.

Regulatory control of the amidotransferase domain of carbamoyl phosphate synthetase.

The 3 order of magnitude increase in the rate of

 and bicarbonate is indicative of the allosteric communication between two of the three reaction centers of CPS.

, the kcat for glutamine hydrolysis increases from 0.17 to 150 min-1.

The glutamine cyclotransferase reaction of Streptococcus bovis: a novel mechanism of deriving energy from non-oxidative and non-reductive deamination.

Stationary S. bovis cells had essentially no intracellular ATP or membrane potential (delta psi), however, when they were provided with

 and delta psi increased to 0.52 mM and 158 mV, respectively.

Properties of ATP-induced chlorophyll luminescence in chloroplasts.

 stimulates luminescence by a 2-fold mechanism: (a) increasing the … of the reducing primary electron acceptor of Photosystem II, 

, and (b) creating a transmembrane electrochemical potential which serves to decrease the … energy required for the charge recombination reaction which leads to luminescence.

In vivo conversion of 5-oxoproline to glutamate by higher plants.

The role of O2-limitation in control of nitrogenase in continuous cultures of Rhizobrium sp.

It is suggested that the restricted supply of

 synthetase during O2-limited growth, thus preventing repression of nitrogenase in the presence of excess ammonium ions.

Carbamylphosphate synthetase from Salmonella typhimurium. Regulations, subunit composition, and function of the subunits.

; it is increased as glutamine concentratiions decrease, an effect that could serve to insulate the cell against major changes in carbamylphosphate synthesis in response to fluctuations in concentration of glutamine.

Regulation of Escherichia coli glutamine synthetase. Evidence for the action of some feedback modifiers at the active site of the unadenylylated enzyme.

 dramatically sharpens the alanine line width when manganese and 

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Possible Interaction: Adenosine Triphosphate and Glutamine

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Research Papers that Mention the Interaction