Possible Interaction: Adenosine Triphosphate and Glutamic Acid

“Mitochondrial depolarization (MD) plays a central role in this Ca(2+) deregulation: it inhibits the uniporter-mediated Ca(2+) uptake and reverses ATP synthetase which enhances greatly ATP consumption during Glu exposure.”

“Elliott has dascribed the preparation of an enzyme system from sheep brain which catalyses the formation of glutamine from glutamic acid in the presence of adenosinetriphosphate.”

“ ATP , but not nonhydrolyzable analogues, induced depolymerization of Glu microtubules in cell models.”

“The maximum rate of the ATP binding/phosphoryl transfer reaction was reduced 3.6-fold in mutant Gly233 → Glu and more than 50-fold in mutant Lys684 → Arg, relative to wild type.”

“Addition of 5 mM glutamic acid to the perfusate significantly increased the ATP level in anoxic heart.”

“As a result, the CP and ATP contents were three- and two-fold higher, respectively, after addition of glutamic acid as compared to control underperfused hearts.”

“ ATP , AMP, DPN, TPN, oxalacetate have a stimulatory effect on the catabolismof glutamic acid by rat kidney or brain homogenates.”

“Gly and Glu significantly reduce the production of intracellular reactive oxygen species and the levels of malondialdehyde and carbonylated proteins and concomitantly increase ATP levels in P. pentosaceus R1 under H2O2-induced stress (P < 0.05).”

“Mutation of R82 to alanine or glutamic acid increased the apparent Km for ATP by more than 20-fold and lowered the kcat/Km with ATP more than 30-fold.”

“As proposed earlier by Meister and others, Glu attacks the gamma-phosphorus atom of ATP to produce gamma-glutamyl phosphate and ADP. (”