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Last Updated: a year ago

Possible Interaction: Adenosine Triphosphate and Glucosamine

Research Papers that Mention the Interaction

GlcN non-competitively inhibits basal glucose transport, which in part depends on GlcN-mediated depletion of ATP stores.
Osteoarthritis and cartilage  •  2009  |  View Paper
Furthermore, glucosamine (>0.1 mM) inhibited the extracellular release of granule contents ( ATP and platelet factor 4) and production of thromboxane A2 from ADP-stimulated platelets (p < 0.05).
Inflammation Research  •  2004  |  View Paper
Glucosamine also acutely reduced cellular glucose uptake, glucokinase activity and intracellular ATP levels.
Neuroscience Letters  •  2010  |  View Paper
Incubation of diaphragm muscles with 10 mM glucosamine for 3 h resulted in an approximately fivefold increase in UDP-HexNAcs, an approximately 50% reduction in insulin responsiveness of glucose transport, and a 58% reduction in ATP concentration.
American journal of physiology. Endocrinology and metabolism  •  2003  |  View Paper
Measurement of intracellular ATP demonstrated that the effects of glucosamine were highly correlated with its ability to reduce ATP levels.
The Journal of Biological Chemistry  •  1998  |  View Paper
In adult retina d -glucosamine markedly inhibits [ 3 H]leucine incorporation into the acid-insoluble fraction and causes a clear reduction of the ATP level.
Experimental eye research  •  1977  |  View Paper
The retinal content of ATP shows a modest increment after incubation with low concentrations of D-glucosamine (0.5--2.0 mM) and a remarkable fall at higher concentrations.
Biochimica et biophysica acta  •  1975  |  View Paper
Both effects seem to result from a rapid loss of adenosine triphosphate and uridine triphosphate during incubation of the cells with high concentrations of glucosamine , which loss is caused by the rapid phosphorylation of the glucosamine taken up by the cells.
Cancer research  •  1973  |  View Paper
Glucosamine in the absence or in the presence of low (1 mm) concentrations of glucose caused a significant reduction of the intracellular ATP pool.
The Journal of biological chemistry  •  1969  |  View Paper
Exposure to glucosamine reduced survival of cultured Schwann cells and neurons accompanied by increased expression of cleaved caspase 3, CCAT-enhancer-binding homologous protein and mitochondrial hexokinase-I, along with ATP depletion.
Brain communications  •  2020  |  View Paper