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Last Updated: 2 years ago

Possible Interaction: Adenosine Triphosphate and Fluorides

Research Papers that Mention the Interaction

When expressed in Escherichia coli fused to a maltose-binding protein, the enzyme catalysed asymmetric cleavage of Ap4A to AMP and ATP which was inhibited at concentrations of F- as low as 3 microM. These are properties characteristic of Ap4A hydrolase (asymmetrical) (EC 3.6.1.
The Biochemical journal  •  1998  |  View Paper
These data suggest: (i) that fluoride interacts directly and slowly with the insulin receptor, which causes inhibition of its phosphotransferase activity; (ii) … fact that fluoride inhibits phosphotransferase activity in the absence of alterations in the binding of ATP, Mn2+ or insulin, we speculate that fluoride binding … ATP to … substrates.
The Biochemical journal  •  1993  |  View Paper
In normal RBCs, fluoride inhibited PRPP formation, caused adenosine triphosphate (ATP) depletion, prevented 2,3-diphosphoglycerate (DPG) depletion, and inhibited pentose phosphate shunt (PPS) activity.
Blood  •  1988  |  View Paper
Even though the ATP concentration was independent of the growth rate under these conditions, fluoride produced a characteristic metabolic alteration in these cells.
When fluoride was present during the entire experimental period, HeLa cells maintained an ATP concentration only slightly below control cells; but when fluoride was added to rapidly growing cells, a rapid decrease in cellular ATP was observed.
Experimental cell research  •  1967  |  View Paper
Thus, fluoride induced the mitochondrial dysfunction in cardiomyocytes by damaging the structure of mitochondrial and interfering with the synthesis of ATP.
Biological Trace Element Research  •  2017  |  View Paper
Moreover, the observation that fluoride mimicked the inhibitory action of ATP suggests the activation of G proteins during purinergic receptor stimulation.
The Journal of general physiology  •  2000  |  View Paper
Inhibitors acting on the glycolytic pathway (2-deoxy-D-glucose, iodoacetamide or fluoride ) strongly decreased aerobic lactate production and ATP concentration, consistent with the belief that articular cartilage obtains its principal supply of ATP from substrate-level phosphorylation in glycolysis.
The Biochemical journal  •  1997  |  View Paper
Exposure of cardiac or … muscle SR to fluoride in the presence of both Ca2+ and ATP resulted in concentration-dependent stimulatory effect of fluoride on Ca2+ uptake with no change in EP formation or Ca(2+)-ATPase activity, this effect diminished substantially at saturating oxalate concentration in the assay.
Biochimica et biophysica acta  •  1994  |  View Paper
The amplitude of the ATP transient is decreasing with increasing free [Ca2+] in the range of 1 nM to 30 microM. In the presence of fluoride , the ATP transient is significantly enhanced and its declining phase is substantially retarded.
Biochemistry  •  1992  |  View Paper
The binding of F- and G-actins are mutually competitive and are inhibited by ATP , suggesting that both forms of actin bind to the same sites.
The Journal of cell biology  •  1991  |  View Paper
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