Possible Interaction: Adenosine Triphosphate and Ferric Ion

“10.0 mM Ca++ or 3.6 mM Fe++ speed up ATP hydrolysis after 30- and 60-minute incubation.”

“On the contrary, 3.6 mM Fe+++ decreases ATP hydrolysis in this medium.10.0 mM F− raises the degree of ATP hydrolysis which is, however, lowered in the presence of 2.5 mM pCMB or 3.6 mM KCN.”

“ Ferric and aluminum complexes with ATP have shown the induction of tumors in the site of subcutaneous injection, whereas sodium ATP has not.”

“… ferric lactate … sodium ATP , and the steady high effect of ferric-ATP complex appear to indicate that ATP might play an important role in the in vivo … can induce the modification of the hepatocytes calcium homeostasis, the event that might be one of the factors triggering the malignant transformation.”

“The involvement of ATP in the action of ferric lactate seems related to a higher stability of the complex, and to a larger availability of active iron able to perform the inhibitory process.”