Possible Interaction: Adenosine Triphosphate and Ethanol

“Using pancreatic duct epithelial cells (PDEC), we found that a micromolar range of ATP reverses all intracellular toxicity mechanisms triggered by exceptionally high doses of ethanol and, thus, improves cell viability dramatically.”

“Exposure of healthy human volunteers to a single dose of ethanol resulted in increased serum levels of uric acid and ATP.”

“ ATP inhibited 4-MU glucuronidation when polyoxyethylene cetyl alcohol ether (Brij-58)-treated RLM were used (IC50 = approximately 70 μM).”

“Here we show that chronic ethanol feeding decreases the ability of pancreatic β-cells to mediate insulin secretion and ATP production in coordination with the decrease of glucokinase, Glut2, and insulin expression.”

“ Ethanol up-regulates the cholesterol transporter ATP binding cassette A1 and cholesterol efflux from primary astrocyte cultures without affecting cholesterol synthesis.”

“2 In the wild‐type receptor, 50, 200 and 500 mM ethanol increasingly shifted the ATP concentration–response curve to the right in a parallel manner, increasing the EC50 value without affecting Emax.”

“ethanol inhibition was not associated with an increased EC50 value of the ATP concentration–response curve, instead, ethanol decreased the maximal response to ATP without affecting the EC50 value of the ATP concentration–response curve.”

“There is some evidence that ATP degradation by "Na-K ATPase" is increased after ethanol feeding and that hepatic O2 consumption is likewise enhanced.”

“Mean hepatic tissue levels of glycogen and ATP , as well as the NAD+/NADH ratio and energy charge, were less for pigs fed ethanol than for controls.”

“ ATP production was significantly decreased by ethanol extracts of the inner scales of the bulb.”

“ Ethanol also increased the affinity of the enzyme for ATP to a larger extent and additively, when compared to calmodulin.”