Possible Interaction: Adenosine Triphosphate and Epinephrine

“In addition, epinephrine (1 microM), a receptor-mediated activator of adenylyl cyclase, stimulated ATP release from rabbit RBCs.”

“Incubation of rabbit erythrocytes with iloprost (n=18) or epinephrine (n=6) increased the ATP concentration by 106+/-16% and 156+/-54%, respectively.”

“Secretion of ATP in response to ADP or epinephrine was completely inhibited, whereas secretion as well as thromboxane synthesis in response to high concentrations of collagen, arachidonic acid, calcium ionophore A23187, or thrombin was unaffected.”

“Lipolytic agents adrenaline , caffeine) markedly depressed the ATP levels.”

“In these platelet preparations, aggregate formation in response to α,β‐Me‐ATP alone was less than that observed in heparin; however, α,β‐Me‐ATP significantly potentiated platelet aggregate formation when added in conjunction with other weak platelet agonists [ epinephrine or thrombopoietin (TPO)].”

“Also abnormal was the fall in metabolic ATP concentration during stimulation with adrenaline and especially with thrombin when the platelets were incubated in glucose‐free medium.”

“Further experiment found that 10(-4) mol L(-1) epinephrine treatment could significantly reduce intracellular ROS level and enhance cytoplasmic ATP concentration (p < 0.05), but there was no different in GSH level compared to vitrification group.”

“However, immediately after the pretreatment with epinephrine , the Ca(2+) transients evoked by chemical stimulants (capsaicin, KCl, and ATP ) were markedly potentiated; for example, capsaicin (50 nM, 15 s)-evoked Ca(2+) transient was increased by 106% after epinephrine (P < 0.05; n = 11).”

“After epinephrine treatment, a 1·2‐fold increase of lactate formation and a 20 per cent decrease of ATP concentration was found under normoxic conditions.”

“ Adrenaline pretreatment enhanced [Ca2+]i responses to ATP and PA in both groups; however, the PA-induced increase in [Ca2+]i, unlike the ATP-induced increase, was lower in the diabetic group compared to the control cells with similar pretreatment with adrenaline.”