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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Epigallocatechin
Research Papers that Mention the Interaction
“We found that EGCG directly interacted with GRP78 at the ATP-binding site of protein and regulated its function by competing with ATP binding, resulting in the inhibition of ATPase activity.”
(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.“Additionally, EGCG reduced ΔΨm, thereby decreasing intracellular ATP concentrations in promastigotes.”
“In addition, EGCG promotes ROS production as a part of its mechanism of action, resulting in decreased ΔΨm and reduced intracellular ATP concentrations.”
The Effect of (-)-Epigallocatechin 3-O - Gallate In Vitro and In Vivo in Leishmania braziliensis: Involvement of Reactive Oxygen Species as a Mechanism of Action“Moreover, EGCG prevented the binding of adenosine 5'-triphosphate and TPA to PKC, resulting in inhibition of PKC activation.”
Sealing effects of (-)-epigallocatechin gallate on protein kinase C and protein phosphatase 2A.
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