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Last Updated: 3 years ago
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“Furthermore, EGCG decreased the level of intracellular ATP , while glucose uptake from culture media was promoted possibly for energy homeostasis.”
(-)-Epigallocatechin-3-O-gallate at a high concentration may induce lipolysis via ATP consumption by activation of stress defense mechanisms.“ EGCG modulates its effect by interacting with ATP binding pocket; the residues likely to be involved in EGCG binding were predicted by Autodock.”
“Molecular docking studies show that EGCG binds well to the PI3K kinase domain active site, agreeing with the finding that EGCG competes for ATP binding.”
“Moreover, we observed a dose‐dependent decrease in intracellular ATP levels in cells treated with high‐dose EGCG.”
“Moreover, EGCG affected glucose, lactate and ATP levels.”
Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models.“ EGCG treatment reduced mitochondrial membrane potential by 56.8% and intracellular ATP levels by 49.1% compared to controls.”
“Moreover, the addition of ATP to samples in the presence of EGCG and Ca2+ led to an early increase in phosphoenzyme followed by a time-dependent decay that was faster when the drug concentration was raised.”
“In addition, a 10-fold higher concentration of EGCG reduced the channel sensitivity to ATP , but not AMP and ADP.”
“Kinetic analysis suggests that EGCG functions as a noncompetitive inhibitor against ATP.”
“Moreover, adenosine triphosphate ATP ) release from dense granule was inhibited by GTC in washed platelets.”
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