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Last Updated: 3 years ago
supplement:
Ebselen
Research Papers that Mention the Interaction
“Nrf2 activators, specifically ebselen , could maintain high ATP levels during preservation.”
Ebselen Preserves Tissue-Engineered Cell Sheets and their Stem Cells in Hypothermic Conditions“ Ebselen inhibited the abilities of NS3 to unwind nucleic acids, to bind nucleic acids, and to hydrolyze ATP , and about 1 μM ebselen was sufficient to inhibit each of these activities by 50%.”
“The plasma membrane-bound enzyme exhibited a pH 6.5 optimum for ATP hydrolysis, Km and Vmaxvalues of … μmol mg−1 min−1, respectively, and an apparent Ki for vanadate inhibition of 1.6 μM. ATP hydrolysis in plasma membranes … cells were inhibited by ebselen , a nonspecific … also fungicidal.”
“Furthermore, the ATP content and Na+-K+-ATPase activity in mitochondria were increased by ebselen after SCI, while the mitochondrial membrane potential (MMP) was decreased by ebselen.”
Ebselen protects mitochondrial function and oxidative stress while inhibiting the mitochondrial apoptosis pathway after acute spinal cord injury“For the treatment with Ebs , the NTPDase activity for ATP substrate was significantly lower in groups II, III and IV (p < 0.05) after 3 days, while after 21 days, a reduction was observed in group III (p < 0.05).”
“Our results showed that ebselen , at final concentrations of 30 and 100 microM, inhibits in vitro ATP extracellular hydrolysis by 48 and 60%, respectively.”
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