Possible Interaction: Adenosine Triphosphate and Cysteine

“Conclusions: A selective Cys in ATP synthase &agr; subunit is targeted by multiple Ox-PTM suggesting that this Cys residue may act as a redox sensor modulating ATP synthase function.”

“Prior studies of several Hsp70 family members show this cysteine is not required for Hsp70 ATPase activity, yet select amino acid replacements of the cysteine can dramatically alter ATP hydrolysis.”

“Hence, the functional coupling between ATP and 2‐Cys Prx gives novel insights into not only the removal of reactive oxygen species, but also mechanisms that link the energy status of the cell and the oxidation of cysteine residues.”

“ ATP or suramin, a purinergic receptor antagonist, significantly inhibited the effect of l-cysteine in neonatal bladders, whereas the nitric-oxide synthase inhibitor Nω-nitro-l-arginine was ineffective.”

“Since mutation of these residues results in a reduced ATP potency and cysteine cross-linking is prevented in the presence of ATP , we suggested an inter-subunit ATP binding site.”

“These substances inhibited Ca2+ - or guanosine 5'-0-3-thiotriphosphate-induced insulin release from islets permeabilized with streptolysin-O. L-cysteine and NaHS reduced ATP production and attenuated glucose-induced hyperpolarization of the mitochondrial membrane potential.”

“ ATP also inhibits the enhanced rates of glucose transport observed with concanavalin A, wheat germ agglutinin, spermine, spermidine, cysteine , and glutathione, substances that activate the same glucose transport system as insulin.”

“The addition of an excess amount of cysteine stopped the steady ATP splitting and increased the viscosity.”

“The production of ATP in C. cladosporioides was inhibited by cysteine.”

“A metabolic flux analysis showed that during cysteine supplementation the ATP consumption reduced by 20%.”