Possible Interaction: Adenosine Triphosphate and Cupric Cation

“The effects of ATP on membrane conductance were mimicked by 2′,3′-O-(4-benzoylbenzoyl)-ATP, but not by UTP, adenosine, or 2-methylthio-ATP, and were inhibited by pyridoxal phosphate-6-azophenyl-2′4′-disulfonic acid, adenosine 5′-triphosphate-2′3′-dialdehyde, and Cu2+.”

“Co-application of Cu2+ (1–40 µM) with ATP increased the response by 20%.”

“In oocytes expressing P2X2 receptors, both Cu2+ and Zn2+, in the concentration range 1-130 microM, reversibly potentiated current activated by submaximal concentrations of ATP.”

“Responses to ATP and α,β‐meATP were selectively inhibited by Cu2+ , Zn2+ or La3+, each at a concentration of 1 mm.”

“In the presence of antimycin (but not in its absence) the addition of ATP causes the appearance of the g = 6 signal, characteristic of a3 in partially reduced cytochrome aa3, as well as the g⊥ line of Cu(II).”

“It is found that three key residues (N7, β-phosphate and γ-phosphate) in ATP are important for the efficient catalytic activity and stereocontrol via complexation of the Cu(II) ion.”

“During the shock-adaptation phase, Ag+ led to up to 4 times of biopolymers generation … blank one; Hg2+ inhibited the nitrification process but showed little influence on other parameters; Cu2+ and Ag+ inhibited the … decreased the content of ATP significantly, as well they caused … corresponding CAT and SOD increment.”

“ ATP inhibited both Cu(I) and Cu(II) catalyzed reactions (IC(50) 0.11 and 0.04mM, respectively).”

“ Cu(II ) also decreased sucrose consumption, ATP content and alkaline phosphatase activity of the biofilm.”

“Both Cu(II) and Hg(II) (50 μM) caused upregulation of mRNA expression for an ATP binding protein (ORF2004) and an ATPase (ORF856) with four- to sixfold increases for Hg(II) and 1.4- to 3-fold increases with Cu(II).”