Possible Interaction: Adenosine Triphosphate and Copper

“ ATP responsiveness recovered extremely slowly after copper washout, with full recovery requiring over 1 h. ATP binding facilitated copper binding but not unbinding from this inhibitory site.”

“The limited data available suggest that copper , either indirectly or directly, alters ATP synthase function.”

“To explore the effects of copper (Cu) on energy metabolism and AMPK-mTOR pathway-mediated autophagy in kidney, a total of 240 one-…/kg) for 49 d. Results showed that excess Cu could induce vacuolar degeneration and increase the number of autophagosomes in kidney, and the adenosine triphosphate (… Cu ….”

“Moreover, ATP concentrations significantly decreased in roach exposed to 10 μg/L of copper after 1 day.”

“Besides that, gill cells exposed to ATP and Cu simultaneously, showed an increase in intracellular copper, which was inhibited by vanadate, an inhibitor of P-type ATPase.”

“Following coapplication of both metals for 20 s with ATP , at least 100 μM copper was required to counteract the 10 μM zinc‐induced potentiation.”

“Whereas coapplication of 300 μM copper plus ATP reduced Imax to 36.2 ± 5%, the coapplication of, or 60‐s preexposure by, 10 μM copper reduced Imax to 79 ± 9.2% (p < 0.05) and 39.6 ± 8.7% (p < 0.01), respectively.”

“In the slow phase, ATP started to decrease with the reduction of copper.”

“The presence of ATP clearly stimulated uptake of radiolabeled Cu (64Cu, 10 microM) into canalicular plasma membrane vesicles and, to a lesser extent, also into basolateral plasma membrane vesicles.”

“The levels of transcripts encoding proteins belonging to Light Harvesting Complex II (LHCII), photosystem II (PSII), cytochrome b6f, PSI, LHCI, ATP synthase and proteins involved in repair of PSII and protection of PSI were increased in the alga cultivated with copper.”

“Cd and Cu changed the efficiency of coupling between proton transport and ATP hydrolysis whereas H(+) /PP(i) stoichiometry was not modified.”