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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Carnosine
Research Papers that Mention the Interaction
“Cell viability as determined by ATP in cell lysates was reduced only in the presence of carnosine.”
Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling“ Carnosine decreased the ATP content through inhibiting both mitochondrial respiration and glycolysis pathways in cultured HeLa cells but not SiHa cells.”
“Here we analyzed whether the anti-neoplastic effect of carnosine , which inhibits glycolytic ATP production, can be antagonized by ATP production via oxidative phosphorylation fueled by pyruvate.”
“We observed that 50-100 mM carnosine decreases ATP and ROS concentration and induces cell cycle arrest in G1 phase.”
“ResultsIn 48 h single cultures of fibroblasts and tumor cells, 50 and 75 mM carnosine reduced ATP in cell lysates and dehydrogenase activity when compared to the corresponding untreated control cells.”
Carnosine selectively inhibits migration of IDH-wildtype glioblastoma cells in a co-culture model with fibroblasts
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