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Cardiac Glycosides
Research Papers that Mention the Interaction
“The mechanism by which digitalis inhibits the sodium pump has been established in studies of Na+-K+ ATPase which show that the ability of cardiac glycosides to inhibit adenosine triphosphate (ATP)-supported transport of Na+ is reduced in the presence of elevated levels of K+.”
Effects of digitalis on cell biochemistry: sodium pump inhibition.“Treatment with cardiac glycosides in combination with metabolic preparations ( ATP methionine, vitamin B12, inosine-F, and extract of the heart muscle) leads to a more conspicuous reduction in the symptoms of congestion in the lesser circulation than that encountered in treatment with cardiac glycosides alone.”
“Marked differences were found in the potassium inhibition of SRF glycoside accumulation, and only slight dependence of glycoside binding on adenosine triphosphate was found.”
The uptake and binding of six radiolabeled cardiac glycosides by guinea-pig hearts and by isolated sarcoplasmic reticulum.“I t is well known that under normal conditions the red cell membrane uses energy from the hydrolysis of ATP to pump sodium outward and potassium inward, and that both the active movements of ions and the associated hydrolysis of ATP are inhibited by cardiac glycosides.”
The Relation between Ouabain-Sensitive Potassium Efflux and the Hypothetical Dephosphorylation Step in the "Transport ATPase" System
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