Possible Interaction: Adenosine Triphosphate and Carboxyamidotriazole

“ CAI also increased the activity of ATP synthase as well as protein expression of ATP5D, δ subunit of ATP synthase.”

“In addition, CAI increased the content of adenosine triphosphate (ATP), decreased the activity, mRNA and protein expression of alkaline phosphatase (ALP) and reduced the production of superoxide anion in calcified aortic tissue.”

“Cells depleted of ATP show not only a strongly inhibited rate of Na-Ca exchange and Na-Na exchange, but also a strongly reduced degree of activation by Cai , even in ATP-depleted cells with no acidosis.”

“A second, much larger increase in Cai was observed on addition of 300 μm ATP.”

“Maximal doses caused Cai to increase from 52 to 248 nM (thrombin), 556 nM (BK), and 643 nM ( ATP).”

“The results show the following: (a) internal alkalinization activates both Cao- and Nao- dependent Na efflux components provided that Cai is present; (b) Mgi … common site; (d) ATP gamma S activates both Nao- and Cao- dependent Na efflux components only in the presence of Cai; and (e) ATP … Cai.”

“ ATP increases the affinity of the transport mechanism for both Cai and Nao, but it does not affect the maximal transport rate at saturating [Ca2+]i and [Na+]o; this suggest that ATP may be acting as a catalyst of modulator, and not as an energy source.”