Possible Interaction: Adenosine Triphosphate and Capsaicin

“In addition, capsaicin stimulated the formation of reticular mitochondria, augmented mitochondrial membrane potential, increased adenosine triphosphate production, and upregulated Mfn2.”

“ CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production.”

“The ATP levels were drastically suppressed by capsaicin treatment in both BxPC-3 and AsPC-1 cells and attenuated by catalase or EUK-134.”

“At a negative holding potential, the P2X3 receptor agonist α,β‐meATP induced less current in the presence of the TRPV1 agonist capsaicin than that in its absence.”

“Electrophysiology experiments show that either ATP or PIP2 prevent desensitization to repeated applications of capsaicin , i.e., tachyphylaxis, while calmodulin plays an opposing role and is necessary for tachyphylaxis.”

“In cells expressing TRPV1, ATP increased the currents evoked by capsaicin or protons through activation of P2Y metabotropic receptors in a PKC-dependent manner.”

“ CAP causes mitochondrial membrane potential loss, inhibits ATP synthesis and reduces mitochondrial Bcl-2 protein production.”

“In summary, these results suggest that CAP induces cytotoxicity by disturbing mitochondrial potential, and inhibits ATP synthesis in NET cells.”

“We demonstrated that CPS induces pre- and early apoptotic cell surface exposure of calreticulin (CRT), HSP90, and HSP70 as well as ATP release.”

“The same concentration of capsaicin induced the release of about 7 fmol adenosine triphosphate per mg.”

“It has been reported that ATP , one of the inflammatory mediators, potentiates the VR1 currents evoked by capsaicin or protons and reduces the temperature threshold for activation of VR1 through metabotropic P2Y1 receptors in a protein Kinase C (PKC)-dependent pathway, suggesting the phosphorylation of VR1 by PKC.”