supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Caffeine
Research Papers that Mention the Interaction
“ Caffeine increased the transformation of ADP to ATP and activated the cAMP/CREB/SIRT3/AMPK/ACC pathway in the liver.”
Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway.“In addition, we show that caffeine inhibits immunoprecipitated and purified DNA-PK, as well as DNA-PK in cell extracts, with an IC50 of 0.2-0.6 mM. Caffeine inhibited DNA-PK activity through a mixed non-competitive mechanism with respect to ATP.”
“Increase of intracellular free Ca2+ Caf ) plays an important role in the deterioration of cell structure that occurs during depletion of adenosine triphosphate (ATP).”
“A 10-min pretreatment with 10(-4) M caffeine partly reversed this inhibition, by 55% in the case of adenosine and 60% for ATP.”
“Lipolytic agents (adrenaline, caffeine ) markedly depressed the ATP levels.”
“These findings suggest that abstinence from caffeine before ATP stress testing may be needed.”
“The ATP-induced [Ca2+]i rise was abolished in Ca2+-free solution and was reduced to 30.1±5.5% (n=14) of the control response when ATP was applied immediately after caffeine , and to 23.7±3.8% (n=11) in the presence of thapsigargin.”
“ ATP caused both Ca2+ entry and Ca2+ release from a ryanodine‐ and caffeine‐sensitive store.”
“The addition of 15 mM caffeine to saponin‐skinned human muscle fibers from M. vastus lateralis caused in the presence of 2 mM ATP an approx.”
“The results clearly showed that caffeine and pentoxifylline were competitive inhibitors of ATP in the enzymatic phosphorylation.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback