Possible Interaction: Adenosine Triphosphate and Biotin

“In dispersed cell culture, Biotin also significantly increased ATP production, assessed using a Seahorse bio-analyzer.”

“BACKGROUND Biotin may activate the acetyl-CoA-, 3-methylcrotonyl-CoA-, propionyl-CoA-, and pyruvate carboxylases to increase myelin repair and/or synthesis, and may enhance the production of adenosine triphosphate (ATP), which may be essential to prevent neurodegeneration.”

“ Biotin treatment increased islet ATP content (control: 4.68+/-0.28; biotin treated: 6.62+/-0.26 pmol/islet) at 30 min.”

“Our data indicate that biotin enhances ATP synthesis in islets following the increased rate of substrate oxidation in mitochondria and that, as a consequence of these events, glucose-induced insulin release is reinforced by biotin.”

“ Biotin inhibited an increase of myocardial water content, an elevation of plasma lactate dehydrogenase activity and a decrease of myocardial adenosine triphosphate (ATP) level in isoproterenol-treated rats.”

“Tight regulation of biotin biosynthesis is important because production of biotin is an energetically expensive process requiring 15–20 equivalents of ATP.”

“The protease susceptibility of this linker region was considerably reduced in the presence of ATP and biotin.”

“Biotinyl 5′-adenylate or biotin plus ATP are more effective corepressors than biotin alone, suggesting that biotinyl 5′-adenylate, a presumed intermediate in the holoenzyme synthetase reaction, is the true corepressor.”