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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Data show that millimolar ascorbate , acting as a pro-oxidant, induced DNA damage and depleted cellular adenosine triphosphate (ATP), activated the ataxia telangiectasia mutated (ATM)/adenosine monophosphate–activated protein kinase (AMPK) pathway, and resulted in mammalian target of rapamycin (mTOR) inhibition and death in ovarian cancer cells.”
High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy“ AA reduced ATP levels in both MCF-7 and MCF-7/Adr cells, and pretreating AA-stimulating cells with catalase completely rescued ATP levels.”
Ascorbate promotes the cellular accumulation of doxorubicin and reverses the multidrug resistance in breast cancer cells by inducing ROS-dependent ATP depletion“ ATP concentrations were adversely affected by the presence of ascorbate.”
“At 10 μM Asc , A23187 and ATP caused an inhibition of Asc accumulation but at 5 mM Asc, both the agents caused a stimulation.”
“ Ascorbate treatment for 14 days led to a fourfold increase in respiration, a threefold increase in ATP production, and a fivefold increase in ATP content compared with that shown in immature cells.”
“At the … with ascorbate had an immediate, positive effect on the recovery of high energy phosphates … of PCr/(PCr+Pi) was 86% higher (p < 0.001) and the ATP level was 40% higher (p < 0.001) in the treated … the control group by the end of the reperfusion period.”
“In the presence of 1 mM pyrophosphate (PPi) ascorbate and adenosine triphosphate ( ATP ), the TR was dramatically enhanced.”
“When isolated, stroma-free thylakoids are illuminated in the presence of ADP … in the absence of any electron acceptor except O2, the addition of ascorbate stimulates electron transport through the formation of … monodehydroascorbate and the coupled synthesis of ATP (G. Forti and G. Elli […] Plant Physiol 109: 1207–1211).”
Stimulation of Photophosphorylation by Ascorbate as a Function of Light Intensity“In the presence of ascorbate the net O2 exchange balance of the Mehler reaction is close to zero, and the synthesis of ATP is increased 2 to 3 times due to the extra electron transport to the monodehydroascorbate free radical.”
“The biological iron chelating compounds such as ATP , ADP, citrate and pyrophosphate suppressed both ascorbate autoxidation and ascorbate-mediated .OH production, thereby indicating that these compounds suppress the activating effect of iron.”
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