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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Adenosine Triphosphate and Ascorbate

Research Papers that Mention the Interaction

Data show that millimolar ascorbate , acting as a pro-oxidant, induced DNA damage and depleted cellular adenosine triphosphate (ATP), activated the ataxia telangiectasia mutated (ATM)/adenosine monophosphate–activated protein kinase (AMPK) pathway, and resulted in mammalian target of rapamycin (mTOR) inhibition and death in ovarian cancer cells.
Science Translational Medicine  •  2014  |  View Paper
AA reduced ATP levels in both MCF-7 and MCF-7/Adr cells, and pretreating AA-stimulating cells with catalase completely rescued ATP levels.
Free radical research  •  2019  |  View Paper
ATP concentrations were adversely affected by the presence of ascorbate.
Transfusion  •  1977  |  View Paper
At 10 μM Asc , A23187 and ATP caused an inhibition of Asc accumulation but at 5 mM Asc, both the agents caused a stimulation.
British journal of pharmacology  •  2006  |  View Paper
Ascorbate treatment for 14 days led to a fourfold increase in respiration, a threefold increase in ATP production, and a fivefold increase in ATP content compared with that shown in immature cells.
American journal of physiology. Cell physiology  •  2000  |  View Paper
At the … with ascorbate had an immediate, positive effect on the recovery of high energy phosphates … of PCr/(PCr+Pi) was 86% higher (p < 0.001) and the ATP level was 40% higher (p < 0.001) in the treated … the control group by the end of the reperfusion period.
Life sciences  •  1995  |  View Paper
In the presence of 1 mM pyrophosphate (PPi) ascorbate and adenosine triphosphate ( ATP ), the TR was dramatically enhanced.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine  •  1985  |  View Paper
When isolated, stroma-free thylakoids are illuminated in the presence of ADP … in the absence of any electron acceptor except O2, the addition of ascorbate stimulates electron transport through the formation of … monodehydroascorbate and the coupled synthesis of ATP (G. Forti and G. Elli […] Plant Physiol 109: 1207–1211).
Plant physiology  •  1996  |  View Paper
In the presence of ascorbate the net O2 exchange balance of the Mehler reaction is close to zero, and the synthesis of ATP is increased 2 to 3 times due to the extra electron transport to the monodehydroascorbate free radical.
Plant physiology  •  1995  |  View Paper
The biological iron chelating compounds such as ATP , ADP, citrate and pyrophosphate suppressed both ascorbate autoxidation and ascorbate-mediated .OH production, thereby indicating that these compounds suppress the activating effect of iron.
Indian journal of biochemistry & biophysics  •  1993  |  View Paper
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