Possible Interaction: Adenosine Triphosphate and Arachidonic Acid

“ ATP release had a low response to arachidonic acid (0.37 ± 0.26 nmoles, reference range: 0.6–1.4 nmoles).”

“In B-TECs growing in monolayer, AA induces two different signals: a Ca2+i increase due to Ca2+ entry and an inhibition of store-dependent Ca2+ entry induced by thapsigargin or ATP.”

“The presence of adenosine triphosphate (ATP) (3 m m) increases significantly the maximal incorporation of arachidonic acid by sixfold (4.75+/-0.35 pmol/mg) and ninefold (4.40+/-0.84 pmol/mg) in BBM and BPM, respectively.”

“On the other hand, less ATP was released after platelet activation with collagen and arachidonic acid , suggesting a change in platelet adhesion or a downregulation of endoperoxide synthesis.”

“In addition, ATP is shown to inhibit, and phosphatidylcholine is shown to stimulate, 15-lipoxygenase, suggesting a regulatory role for these compounds in the lipoxygenation of arachidonic acid.”

“ ArA thus blocks release of ATP from glia after nerve injury and thereby, at least in leeches, stops microglia at lesions.”

“ ATP induced by SCI could mobilize the release of AA and PGE2.”

“We have explored the signaling events involved in this … intracellular Ca2+ via P2Y1 receptor; (3) we indicated that ATP … AA and PGE2 which involved the transactivation of epidermal growth factor (EGF) receptor, the phosphorylation of …, but the activation of Akt has no effect on the downstream of cPLA2 phosphorylation.”

“Furthermore, AA reduced intracellular NAD, ATP and membrane potentials, which indicated dysfunction of the mitochondrial membrane.”

“Co-administration of AA and Glu caused 2–3 times more pronounced decrease in ATP concentrations than that observed during the independent effect of AA and Glu.”

“Atractyloside potentiated and ATP inhibited the arachidonic acid induced swelling.”