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Last Updated: 3 years ago
supplement:
Apigenin
Research Papers that Mention the Interaction
“Hence, apigenin may compete with ATP for NDB-binding leading to energy depletion to fuel the transport of ABC transporter substrates.”
Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking.“The production of ATP and the total oxygen uptake were also promoted after apigenin administration.”
Apigenin prevents TNF-α induced apoptosis of primary rat retinal ganglion cells.“Our study indicates that apigenin inhibited PKC by competing with adenosine triphosphate (ATP).”
“Our study shows that apigenin inhibits PKC by competing with ATP , and exhibits an IC50 value of 10 +/- 0.5 microM. Apigenin also reduces the level of TPA-stimulated phosphorylation of cellular proteins.”
“Kinetic analyses indicated that the flavone apigenin [2] was a competitive inhibitor of p40 with respect to ATP.”
“ Apigenin significantly inhibited cell viability with a concomitant increase in intracellular reactive oxygen species (ROS) and caused the loss of mitochondrial membrane potential (ΔΨm), and ATP depletion, resulting in apoptosis and necroptosis in monolayer cell culture.”
Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells
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