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Last Updated: 5 years ago
supplement:
Anthocyanins
Research Papers that Mention the Interaction
“The results showed that pretreatment with anthocyanins significantly inhibited Aβ1-42-induced apoptosis, decreased intracellular calcium and ROS, and increased ATP and mitochondrial membrane potential.”
Anthocyanins Extracted from Aronia melanocarpa Protect SH-SY5Y Cells against Amyloid-beta (1-42)-Induced Apoptosis by Regulating Ca2+ Homeostasis and Inhibiting Mitochondrial Dysfunction.“The treatment of ATCs resulted in a decrease in intracellular ATP contents and the activation of AMPK by AICAR treatment also induced autophagy.”
“In addition, the treatment with Antho prevented the decrease in ATP levels induced by SCO in the CC and HC.”
Protective effects of anthocyanins on the ectonucleotidase activity in the impairment of memory induced by scopolamine in adult rats.“As one of the possible mechanisms, AMP-activated protein kinase activation would be associated with these changes, nevertheless, the AMP ATP ratio was significantly decreased by administration of the anthocyanins.”
“Additionally, this cavity overlapped with ATP binding (MolDock Score = -161 kJ/mol) domain; the binding of anthocyanins presumably interfered the H bond formation between ATP and HER-2.”
“These results indicate that anthocyanins may competitively bind to ATP binding site in HER-2 kinase domain by suppressing HER-2 activation and downstream signaling cascade.”
[Molecular docking of anthocyanins constituents and HER-2 kinase domain].
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