Possible Interaction: Adenosine Triphosphate and Alpha-lipoic acid

“Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion.”

“ ALA activates ATP dependent K+ channels (Na+, K+-ATPase).”

“Moreover, LA upregulated the activities of oxidative phosphorylation complexes and diminished ACR-induced variation in AMPK/GSK3β, Ca2+ disturbance, and ATP depletion.”

“Within 48 hours, exposure to Α-lipoic acid (10 - 75 mM) significantly decreased forward scatter, increased cytosolic Ca2+ concentration, decreased ATP concentration, activated caspase 3, stimulated formation of ceramide and triggered annexin V-binding.”

“ ALA administration significantly improved the ATP levels in the liver, heart and kidney, while Vit E improved the ATP levels in all tissues except the muscle compared to Atorvastatin group.”

“ α-LA significantly reduced energy efficiency, the activity of the electron transport chain complexes and induced a lower efficiency of oxidative phosphorylation with reduced ATP production.”

“Intraperitoneal injection with ALA once a day for 1 week remarkably reduced P2X3R expression and ATP current density in diabetic rats.”

“Moreover adenosine triphosphate and glutathione content of the was increased 1 h after reperfusion by LA.”

“ Adenosine 5'-triphosphate and creatine phosphate contents as well as the ATP/ADP ratio in hypertrophied right ventricle were significantly increased after reoxygenation in hearts treated with lipoic acid.”

“ LA activated Akt signaling and inhibition of Akt signaling abolished the effects of LA on cell viability, NO production, ROS production and ATP levels in UA-treated endothelial cells.”