supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Adenosine
drug:
Ticagrelor
Research Papers that Mention the Interaction
“At 2 h and … d postdrug treatment, the adenosine diphosphate-induced platelet inhibition … (ADP%) in the ticagrelor group increased significantly as compared with that in the clopidogrel group, and the platelet aggregation rate … the ADP pathway (MAADP) decreased significantly in the ticagrelor group versus that in the clopidogrel group.”
Short-term efficacy of ticagrelor in acute ST-segment elevation myocardial infarction patients undergoing an emergency percutaneous coronary intervention“Conclusions: Ticagrelor inhibits cellular adenosine uptake selectively via ENT1 inhibition at concentrations of clinical relevance.”
“ Ticagrelor provides selective and reversible inhibition of adenosine diphosphate-induced platelet aggregation, with a faster onset and offset of action than that of clopidogrel, and is effective in the treatment of patients with ACS, with or without ST-segment elevation.”
“BACKGROUND The positive interaction of ticagrelor with the metabolism of adenosine has been claimed for the large antithrombotic and antiischemic benefits of this antiplatelet agent in acute coronary syndromes (ACS).”
“Purpose Since ticagrelor inhibits the cellular uptake of adenosine , thereby increasing extracellular adenosine concentration and biological activity, we hypothesized that ticagrelor has adenosine-dependent antiplatelet properties.”
“ Ticagrelor's pleiotropic effects on reuptake of adenosine via inhibition of equilibrative nucleoside transporter 1 (ENT1) have been hypothesized to contribute to this.”
“ Ticagrelor has been reported to increase plasma adenosine levels, which might have a protective effect on the microcirculation.”
“… ticagrelor … adenosine plasma levels and explain drug-related dyspnea.3 However, the identification of a pattern of periodic breathing associated to increased chemosensitivity to hypercapnia in … patients with and without dyspnea while on treatment with ticagrelor may help unraveling the mechanism of this common and clinically relevant side effect.”
“ Ticagrelor induces an increase in the level of adenosine that produces a series of adenosine‐mediated biological effects, such as inhibition of platelet aggregation, relaxation of blood vessels, and protection of heart muscle.”
“The effect of ticagrelor on adenosine may explain these results.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback