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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Tiazofurin
Research Papers that Mention the Interaction
“Similar findings were obtained with GTP gamma S. These effects of tiazofurin treatment on guanine nucleotide binding were also associated with decreased adenosine diphosphate-ribosylation of specific G protein substrates by cholera and pertussis toxin.”
Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL-60 cells.“The maximal uptake of tiazofurin was 8.29 +/- 0.84% and was shown to be both carrier-mediated, sodium-dependent and inhibited by adenosine which suggests that it uses the carrier for endogenous nucleosides.”
The kinetics of tiazofurin uptake by the isolated perfused choroid plexus of the sheep.“Introduction … adenosine into the perfusing medium (0.005-0.2 mmol/l) caused similar but more rapid decrease of [3H]-tiazofurin brain clearance (Ki = 6.36 +/- 3.14 x 10(-6) mol/l for nucleus caudate and 11.74 +/- 4.85 x 10(-6) mol/l for cerebral cortex).”
“Mycophenolic acid (MPA) and tiazofurin inhibit inosine-monophosphate dehydrogenase, a’ key-enzyme’ of the purine pathway.”
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