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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Theophylline
Research Papers that Mention the Interaction
“ Adenosine is a neuromodulator with mostly inhibitory activity that is released by physiological stimuli and can be blocked by non-selective adenosine receptor antagonists such as theophylline and caffeine.”
Caffeine modulates P50 auditory sensory gating in healthy subjects“Vasoconstriction produced by adenosine can be inhibited by the nonspecific adenosine receptor antagonist, theophylline.”
“RESULTS At therapeutic levels th ophylline in creased FEV1 at baseline and during the allergen challenge and increased the percentage suppression of neutrophil superoxide production by ade nosine. ”
“The vasodilatory effect of adenosine was readily counteracted by theophylline , the increase in CS flow being 33% vs. 133% in the control situation.”
“ Theophylline is a competitive receptor antagonist of adenosine and may have a potential as an anti-ischemic medication.”
“BACKGROUND Th ophylline is a competitive antagonist of ade nosine an d may have potential as an anti-ischemic medication.”
“The increase in heart rate observed during adenosine infusion was significantly reduced by theophylline pretreatment.”
“In conclusion, theophylline has a small but significant inhibitory effect on the ischaemic pain sensation compatible with a hyperalgesic effect of adenosine.”
“Compared with placebo theophylline caused a small increase in minute ventilation (P less than 0.05) and flattened the dose-response curves of the effects of adenosine on ventilation (P less than 0.01) and Pa, CO2 (P less than 0.01).”
“ Theophylline did not by itself affect heart rate but significantly (P less than 0.05) reduced the heart rate response to adenosine.”
“At therapeutic concentrations theophylline is a specific antagonist of the airway effects of adenosine in addition to being a bronchodilator and a functional antagonist.”
“However theophylline had a greater protective effect against adenosine (concentration-ratio 17.4 for FEV1 and 12.8 for sGaw) than against histamine (concentration ratio 5.6 for FEV1 and 5.4 for sGaw (P less than 0.05].”
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