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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Adenosine
drug:
Theobromine
Research Papers that Mention the Interaction
“Chocolate contains caffeine and theobromine , which are methylxanthines and are competitive antagonists of adenosine and can have arrhythmogenic potential.”
Supraventricular tachycardia induced by chocolate: is chocolate too sweet for the heart?“The adenosine antagonists theophylline (50 microM), caffeine (50 microM) and a xanthine derivative, 3,7-dimethyl-l-propargylxanthine (DMPX, 10 microM) (a more specific adenosine A2 receptor antagonist), potentiated PAF activity on platelet aggregation in PRP samples containing adenosine.”
“Vasodilatation due to adenosine was inhibited by the P1‐A2 receptor antagonist 3,7‐dimethyl‐1‐propargylxanthine ( DMPX).”
“Following infusion with selective A2 adenosine receptor antagonist, 3,7-dimethyl-l-propargylxanthine (DMPX) (10 μM), or non-selective adenosine receptor antagonist, theophylline (30 μM), vasodilatation produced by adenosine were significantly reduced at lower doses.”
Vasodilatation produced by adenosine in isolated rat perfused mesenteric artery: a role for endothelium“In contrast to the specific antagonism, theobromine blocked the hypothermia induced by both of these adenosine analogs.”
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