Possible Interaction: Adenosine and Tetrodotoxin

“Bath application of adenosine also reduced the frequency of the miniature EPSCs recorded in the presence of TTX suggesting that adenosine may interact with the exocytosis processes downstream of Ca2+ influx.”

“Blockade of neural activities with tetrodotoxin abolished the stimulatory effect of adenosine on ghrelin release.”

“ Tetrodotoxin (0.5 gmol/1) abolished and absence of Ca2+ markedly reduced the electrically evoked release of adenosine and inosine.”

“Bath application of AD (20 microM) to seven of these neurons had no direct effect but caused a significant decrease in the frequency of spontaneous miniature inhibitory postsynaptic currents in the presence of tetrodotoxin , indicating a presynaptic site of action.”

“In the presence of tetrodotoxin to block action potentials, the frequency, but not the amplitude, of miniature inhibitory postsynaptic currents was significantly reduced (46%) by 1 microM adenosine , suggesting a presynaptic mechanism of adenosine action.”

“Kainate‐evoked release of adenosine was reduced significantly by 10 µM tetrodotoxin and by a κ‐receptor agonist, U50,488H (100 µM).”

“The addition of tetrodotoxin (1 microM) was followed by a decrease in basal adenosine concentration and a partial inhibition of the increase in adenosine evoked by K+ depolarization.”

“Iontophoresis LTP was induced when excitatory postsynaptic potentials were completely blocked by adenosine plus tetrodotoxin.”

“ Tetrodotoxin reduced the outflow of adenosine and inosine by 42 and 33%, respectively, whereas the removal of Ca2+ caused a further increase.”

“ Tetrodotoxin reduced N-methyl-D-aspartate (NMDA)-evoked release of adenosine by 35% but virtually abolished [3H]norepinephrine release.”