Possible Interaction: Adenosine and Taurine

“Extracellular ATP and adenosine increased taurine efflux by potentiating the effect of hypotonic shock.”

“Intracellular cAMP adenosine 3' , 5'-monophosphat) in the stomach significantly increased with taurine treatment in a dose-dependent manner.”

“ Taurine and adenosine may thus not cooperate in developing mice to prevent ischemic neuronal damage.”

“ Adenosine and neurohormones also have opposite actions on the efflux of taurine , a local messenger that is released by pituicytes in hypotonic conditions and accordingly inhibits vasopressin output from axon terminals.”

“The simultaneous release of taurine and adenosine may constitute an important protective mechanism under ischemic conditions.”

“Another inhibitory neuromodulator and cell volume regulator, taurine , was seen to enhance adenosine release in ischemia at both ages.”

“The simultaneous release of taurine and adenosine under cell-damaging conditions could constitute an important protective mechanism against excessive amounts of excitatory amino acids, counteracting their harmful effects and preventing excitation from reaching neurotoxic levels.”

“These findings suggest that endogenous taurine with adenosine may have neuroprotective actions against high K(+)-evoked glutamate release and spreading depression in the rat hippocampus, in addition to its osmoregulatory action.”

“Three‐minute incubations of cells with adenosine caused a dosedependent accumulation of intracellular cAMP and release of the taurine (EC50 = 5.0 × 10−5 M and 1.6 × 10−6 M, respectively).”

“In this region, taurine also reduced the stimulatory effects on cyclic AMP formation of adenosine , norepinephrine, and histamine, but not of depolarizing agents.”

“ Adenosine delivered by microdialysis into the interstitial fluid of nonischemic rabbit hippocampus induces release of taurine in a dose-dependent manner, suggesting involvement of additional mechanisms besides the already known A2-receptor-induced release.”