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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Adenosine and Suramin

supplement:

Adenosine

drug:

Suramin

Research Papers that Mention the Interaction

The purinoceptor P2 blockers, suramin and pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS), inhibited the diadenosine polyphophate-induced [Ca2+]i increase, whereas the P2y purinoceptor blocker, reactive blue, had no effect.
Biochimica et biophysica acta  •  1996  |  View Paper
These results suggest that suramin potentiates the CGS-15943 effects and consequently that adenosine and ATP signaling act in synergy.
American journal of physiology. Regulatory, integrative and comparative physiology  •  2006  |  View Paper
P2-antagonists and diadenosine tetraphosphate (Ap(4)A) progressively and non-competitively inhibited ecto-ATPase activity with the following rank order of inhibitory potency: suramin (pIC(50), 4.570)>Reactive blue 2 (4.297)&z.
Biochimica et biophysica acta  •  2000  |  View Paper
Only responses to low doses of adenosine and ATP were inhibited by suramin.
European journal of pharmacology  •  1994  |  View Paper