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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“In vivo and in vitro studies have shown that, in all brain structures investigated, endogenous NO modulates the release of several neurotransmitters, such as acetylcholine, catecholamines, excitatory and inhibitory amino acids, serotonin , histamine, and adenosine.”
Nitric oxide as modulator of neuronal function“Endogenous adenosine systems contribute to antinociceptive properties of caffeine, opioids, noradrenaline, 5-hydroxytryptamine , tricyclic antidepressants and transcutaneous electrical nerve stimulation.”
“OBJECTIVE Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity.”
“Besides dopamine, adenosine has been shown to inhibit synaptic activity and the release of several neurotransmitters, such as glutamate, acetylcholine and serotonin , by acting on presynaptic A1 receptors (6).”
“PAF at concentrations of 0.1 to 12 microM caused no 5-HT release in PRP containing normal amounts of adenosine (blood … of 2'-deoxycoformycin and dilazep), whereas PAF at 0.1 microM caused 5-HT release (45%) in adenosine-depleted PRP, demonstrating that plasma adenosine is … 5-HT ….”
“ Adenosine is physiological inhibitor of human platelet aggregation in administration of PAF, ADP and 5-HT.”
“BACKGROUND Adenosine , an endogenous nucleoside, modulates the release of monoamines, e.g., noradrenaline, serotonin , and dopamine in the brain.”
Agomelatine and tianeptine antidepressant activity in mice behavioral despair tests is enhanced by DMPX, a selective adenosine A2A receptor antagonist, but not DPCPX, a selective adenosine A1 receptor antagonist.“Taken together, the combination of 5-HT with either gabapentin or adenosine may offer a potential remedy in the treatment of the facilitated state as well as acute pain in the spinal cord.”
“ Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells.”
“This fact suggests the involvement of cyclic 3', 5'-adenosine monophosphate (cAMP) in mediating the action of serotonin.”
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