Possible Interaction: Adenosine and Salicylic Acid

“Antioxidant properties of salicylates, adenosine release induced by sodium salicylate and aspirin-triggered lipoxin formation are additional mechanisms that may contribute to anti-inflammatory properties of aspirin and/or sodium salicylate.”

“This suggests that sodium salicylate inhibits neutrophil adherence by increasing adenosine release.”

“Aspirin and sodium salicylate dramatically increased concentrations of adenosine in exudates, a property shared with methotrexate and sulfasalazine.”

“Cyanide, 2,4‐dinitrophenol, arsenate or salicylate increased the resting efflux of adenosine , inosine and hypoxanthine, and the effect of activity.”

“Complex formation between salicylic acid and adenosine or adenosine triphosphate in 0.2m phosphate buffer at pH=7 was investigated as a potential factor contributing to the prolongation of acetylsalicylic acid-induced GI blood loss.”

“Concerntration dependency of the absorbance decrease was measured at 27 and 37 degrees C. The addition of salicylic acid to either adenosine or adenosine triphosplate solutions appeared also to cause a decrease in surface tension which may play a role in reducing platelet aggregation induced by adenosine diphosphate.”