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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Application of adenosine (1mM) resulted in a time-dependent increase in intracellular adenosine, inosine, AMP, ATP, AdoHcy and AdoMet concentration.”
Adenosine metabolism and its effect on methylation potential in cultured cells: methodological considerations.“We observed that adenosine was able to modulate S‐adenosylmethionine‐dependent trans‐methylation reactions, and recently, we found that IFC‐305 modulates HDAC3 expression.”
Epigenetic Effects of an Adenosine Derivative in a Wistar Rat Model of Liver Cirrhosis“The protective role of SAMe may be partially mediated by the effect of adenosine during liver procurement.”
“ SAM treatment increased the concentration of adenosine but inhibited the accumulation of hypoxanthine in the ischemic liver.”
“ Adenosine (1 mM) increased the level of AdoHcy and S-adenosylmethionine by 20- and 5-fold respectively after 60 min of incubation and reduced the methylation index.”
“An adenosine-sensitive (Ados) mutant of baby hamster kidney (BHK) cells, ara-S10d, when treated with a toxic concentration of adenosine (Ado), displayed a substantial elevation of S-adenosylhomocysteine (SAH), S-adenosylmethionine ( SAM ), and methylthioadenosine (MTA).”
“Compared to parental lymphoma cells, the adenosine resistant mutants had severalfold elevated levels of AdoMet and an increased AdoMet:AdoHcy ratio.”
“ Adenosine was an inhibitor of the reaction, the inhibition being linear competitive against both S-adenosyl-L-methionine (Ki/1.2 times 10-3 mol/1.)”
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