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Last Updated: 6 months ago

Possible Interaction: Adenosine and Rolipram

supplement:

Adenosine

Research Papers that Mention the Interaction

Papaverine, cilostazol, and rolipram also augmented both the magnitude and the duration of Isc following low dose stimulation of adenosine receptors with Ado (0.1-1.0 microM, P < 0.01).
American journal of respiratory cell and molecular biology  •  2003  |  View Paper
This effect of adenosine may not only have a physiological role but also appears to contribute to the pharmacological inhibition of TNF synthesis by exogenous agents such as the specific type IV phosphodiesterase inhibitor rolipram.
Scandinavian journal of immunology  •  1997  |  View Paper
Adenosine (or CGS 21680) combined with rolipram synergistically increased f-met-leu-phe-stimulated PMN cAMP content.
In addition, rolipram especially when combined with adenosine , decreased rhTNF alpha-stimulated PMN adherence to a fibrinogen-coated surface, and the oxidative burst of rhTNF alpha-stimulated adherent PMN.
The effects of both adenosine and rolipram with adenosine could be only partly counteracted by treatment of the PMN with the protein kinase A inhibitor KT 5720, indicating that protein phosphorylation is only partially involved.
Thus, rolipram , especially when combined with adenosine , has potent modulating effects on PMN activation and may be useful in decreasing inflammatory tissue damage in patients with sepsis.
International journal of immunopharmacology  •  1995  |  View Paper
Here, we test the hypothesis that an acute administration of rolipram will increase spinal and medullary levels of 3′,5′-cyclic adenosine monophosphate (cAMP) and induce phrenic nerve recovery after cervical (C2) spinal cord hemisection.
The journal of spinal cord medicine  •  2009  |  View Paper
Effects were enhanced by protecting adenosine using an adenosine deaminase inhibitor or by potentiating the cAMP response with rolipram.
The addition of exogenous adenosine with EHNA or rolipram further suppressed NO production.
Osteoarthritis and cartilage  •  2002  |  View Paper
Ro 20-1724 (1-100 microM), rolipram (1-100 microM), and forskolin (1-10 microM) increased basal release of adenosine , and at 1 microM inhibited morphine-evoked release of adenosine.
Canadian journal of physiology and pharmacology  •  1991  |  View Paper
The non‐xanthine phosphodiesterase inhibitor rolipram (0.1 and 100 μm) caused a slight but non‐significant potentiation of the relaxant effect of adenosine.
British journal of pharmacology  •  1983  |  View Paper