Possible Interaction: Adenosine and Resveratrol

“Whole cell clamping demonstrated that RES significantly inhibited adenosine triphosphate-activated currents in HEK293 cells that were transfected with the P2X7 plasmid.”

“ Resveratrol increased the phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin (mTOR) and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner, leading to autophagy.”

“Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-κB) and immune function.”

“In addition, dietary RSV supplementation caused an age-dependent modulation in both adenosinergic and glutamatergic systems.”

“ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly increased adenosine release and coronary flow compared with baseline.”

“When a subanticonvulsant dose of adenosine (500 mg/kg) was administered together with resveratrol , a significant reduction in the percent incidence of generalized tonic-clonic convulsions was observed.”

“ Resveratrol is known to interact with a variety of proteins that have yeast homologs, such adenosine monophosphate (AMP) kinase, protein kinase C and mitochondrial adenosine triphosphate (ATP) synthase, among others (Kaeberlein & Rabinovitch, 2006).”