Possible Interaction: Adenosine and Rabbit Allergenic Extract

“ Adenosine inhibited the noradrenaline-induced contraction of rabbit corpus cavernosum in a dose-dependent manner.”

“Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine , dipyridamole and chlorpromazine, but not by acetylsalicylic acid.”

“IT is now well known that adenosine and adenosine monophosphate (AMP) strongly inhibit the aggregation of human and rabbit platelets which occurs in the presence of adenosine diphosphate (ADP).”

“ Adenosine and its 2-chloro, 2-methyl, 2-hydroxy, and 2-amino derivatives have been shown to cause with different degrees of potency a transient reduction of tone and spontaneous motility in the isolated intestine of rabbit ; the 2-acetamido derivative has been relatively inactive.”

“Desheathed rabbit vagus nerve has been found to form cyclic AMP when incubated with adenosine.”

“It is concluded that adenosine but not an adenine nucleotide mediates the tonic purinergic presynaptic inhibition of noradrenaline release in rabbit brain cortex.”

“cAMP levels in rabbit carotid bodies superfused in vitro for 10 min were increased in the presence of adenosine (100 microM and 1.0 mM; maximum increase = 127%, P < 0.01).”

“ Adenosine also caused a hyperpolarization (1-5 mV) in 40% of the rabbit neurons and 66% of the feline neurons.”

“Bath application of adenosine (300 microM) depressed the amplitude of nicotinic fast EPSP by 48 +/- 4% in the rabbit ganglia.”

“These data suggest diverse actions of adenosine in modulating cholinergic transmission in rabbit and feline vesical ganglia.”

“CONCLUSIONS The inhibitory effect of ad nosine on ICa in rab bit AV nodal myocytes can be mediated by two mechanisms--stimulation of cGMP-stimulated phosphodiesterase by NO-induced cGMP, and a mechanism which involves interaction with .O2- production.”

“In summary, adenosine shortened the action potential and reduced the twitch shortening of rat and ferret but not of guinea pig and rabbit ventricular myocytes.”