Possible Interaction: Adenosine and Prostaglandin D2

“ PGD2 stimulates DP1 receptors and increases the local extracellular concentration of adenosine in the basal forebrain as a paracrine sleep-promoting molecule.”

“ PGD2 stimulates DP1 receptors localized in the basal forebrain and increases the local extracellular concentration of adenosine , a paracrine signaling molecule, to promote sleep.”

“ PGD2 stimulates DP, receptors localized in the basal forebrain and increases the local extracellular concentration of adenosine , which activates A2A receptor-possessing neurons in the basal forebrain and/or ventrolateral preoptic area (VLPO).”

“ Adenosine may be involved in the signal transduction associated with PGD2.”

“We have recently shown that local airway challenge with adenosine in subjects with asthma and rhinitis provokes an increase in the levels of PGD2 , histamine and tryptase.”

“Submillimolar … of adenosine , NECA and R-PIA inhibited in a … dependent manner the release of histamine and prostaglandin D2 (PGD2) from skin mast cells challenged with anti-IgE. These results demonstrate marked heterogeneity of the modulatory effect exerted by adenosine on mediator release from human basophils and mast cells.”

“ PGD2 activates the PGD2 receptor (DPR) and increases the extracellular level of adenosine in wild-type (WT) mice but not DPR knockout (KO) mice, suggesting that PGD2-induced sleep is DPR-dependent, and adenosine may be the signaling molecule that mediates the somnogenic effect of PGD2.”

“In turn, the somnogenic effects of prostaglandin D2 have been shown to be mediated via increases in adenosine , and a select group of sleep‐active ventrolateral preoptic nucleus (VLPO) neurons are directly activated by adenosine 2A (A2A) agonists.”

“When the indomethacin inhibition of adenosine-induced prostaglandin D2 release was titrated, a close correlation between prostaglandin D2 release and the metabolic and vascular responses to adenosine was observed.”