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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Propranolol
Research Papers that Mention the Interaction
“Both verapamil and propranolol can exhibit additive effects with adenosine in prolonging AV nodal conduction time; however, only verapamil can reduce the dose of adenosine required to produce AV nodal block.”
“In conclusion, the negative dromotropic effects of adenosine are preserved and independent even in the presence of verapamil, propranolol , or procainamide.”
Effects of verapamil, propranolol, and procainamide on adenosine-induced negative dromotropism in human beings.“The effects of epinephrine, histamine, and adenosine were inhibited by the addition of propranolol (a beta-adrenergic antagonist), cimetidine (histamine H2-antagonist), and theophylline (adenosinereceptor antagonist), respectively.”
“ Adenosine significantly lengthened the sinus cycle length in the baseline state (760 ± 165 vs …), during isoproterenol infusion (516 ± 67 vs 766 ± 146 ms, P < 0.05), after propranolol (850 ± 153 vs 914 ± 143 ms, P < 0.05) and after … atropine (662 ± 76 vs 801 ± 121 ms, P < 0.05).”
“In the presence of propranolol plus vagotomy, both the negative chronotropic and dromotropic effects of ATP and adenosine were enhanced and attenuated in a similar manner by dipyridamole and aminophylline.”
Comparative electrophysiologic effects of adenosine triphosphate and adenosine in the canine heart: influence of atropine, propranolol, vagotomy, dipyridamole and aminophylline.
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