Possible Interaction: Adenosine and Propentofylline

“In contrast, A1 and A2A receptor mediated effects of adenosine were enhanced by propentofylline at concentrations of 1 and 100 microM, respectively.”

“Inhibition of [3H]adenosine uptake by propentofylline was concentration dependent, with IC50 values of 37-39 microM for the three cell types.”

“The cAMP-linked homeostatic adenosine effects could be reinforced or mimicked by propentofylline , a pharmacon that raises the effective extracellular concentration of adenosine by inhibiting its cellular reuptake and increases the cellular cyclic nucleotide content by selective phospnodiesterase inhibition.”

“ Propentofylline inhibits the transport of adenosine into cultured cells and increases extracellular adenosine concentrations in ischemic brain.”

“The present results show that propentofylline and its hydroxylated metabolite can influence adenosine mechanisms in a multitude of ways.”

“BACKGROUND Propentofylline is a novel therapeutic agent for dementia that readily crosses the blood-brain barrier and acts by blocking the uptake of adenosine and inhibiting the enzyme phosphodiesterase.”

“Similar effects were obtained with propentofylline , which acts as selective cAMP/cGMP phosphodiesterase inhibitor and also increases the effective concentration of adenosine by blocking its cellular reuptake.”

“A longitudinal analysis of rCMRGl in VD showed that the progression of dementia can be delayed by the adenosine uptake blocker propentofylline and that neuropsychological and metabolic changes are closely related.”

“At 100 microM propentofylline significantly enhanced the effect of adenosine , but not that of NECA.”

“The results demonstrate that propentofylline can counteract neutrophil activation, at least partly by enhancing the action of adenosine through blocking its removal, and that the effect is exerted at a step after the initial receptor events.”

“BACKGROUND Studies showed that propentofylline enhances the action of adenosine and protects hippocampal neuronal damage against transient global cerebral ischaemia.”

“Furthermore, PPF reduced the tissue concentration of adenosine from 17.75 ± 2.79 to 8.83 ± 3.68 pmol/mg wet weight during 4 vo if compared with animals without PPF.”