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Possible Interaction: Adenosine and Propentofylline

supplement:

Adenosine

Research Papers that Mention the Interaction

In contrast, A1 and A2A receptor mediated effects of adenosine were enhanced by propentofylline at concentrations of 1 and 100 microM, respectively.
Inhibition of [3H]adenosine uptake by propentofylline was concentration dependent, with IC50 values of 37-39 microM for the three cell types.
Canadian journal of physiology and pharmacology  •  1998  |  View Paper
The cAMP-linked homeostatic adenosine effects could be reinforced or mimicked by propentofylline , a pharmacon that raises the effective extracellular concentration of adenosine by inhibiting its cellular reuptake and increases the cellular cyclic nucleotide content by selective phospnodiesterase inhibition.
Alzheimer disease and associated disorders  •  1998  |  View Paper
Propentofylline inhibits the transport of adenosine into cultured cells and increases extracellular adenosine concentrations in ischemic brain.
General pharmacology  •  1994  |  View Paper
The present results show that propentofylline and its hydroxylated metabolite can influence adenosine mechanisms in a multitude of ways.
Fundamental & clinical pharmacology  •  1992  |  View Paper
BACKGROUND Propentofylline is a novel therapeutic agent for dementia that readily crosses the blood-brain barrier and acts by blocking the uptake of adenosine and inhibiting the enzyme phosphodiesterase.
The Cochrane database of systematic reviews  •  2003  |  View Paper
Similar effects were obtained with propentofylline , which acts as selective cAMP/cGMP phosphodiesterase inhibitor and also increases the effective concentration of adenosine by blocking its cellular reuptake.
Annals of the New York Academy of Sciences  •  1997  |  View Paper
A longitudinal analysis of rCMRGl in VD showed that the progression of dementia can be delayed by the adenosine uptake blocker propentofylline and that neuropsychological and metabolic changes are closely related.
Journal of neural transmission. Supplementum  •  1996  |  View Paper
At 100 microM propentofylline significantly enhanced the effect of adenosine , but not that of NECA.
The results demonstrate that propentofylline can counteract neutrophil activation, at least partly by enhancing the action of adenosine through blocking its removal, and that the effect is exerted at a step after the initial receptor events.
Biochemical pharmacology  •  1994  |  View Paper
BACKGROUND Studies showed that propentofylline enhances the action of adenosine and protects hippocampal neuronal damage against transient global cerebral ischaemia.
Chinese medical journal  •  2004  |  View Paper
Furthermore, PPF reduced the tissue concentration of adenosine from 17.75 ± 2.79 to 8.83 ± 3.68 pmol/mg wet weight during 4 vo if compared with animals without PPF.
Journal of Neural Transmission  •  1998  |  View Paper
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