Possible Interaction: Adenosine and Potassium

“M. tuberculosis AK activity was dependent on Mg2+, and activity was stimulated by potassium , as reflected by a decrease in the Km and an increase in Vmax for both Ado and methyl-Ado.”

“We show that potassium can inhibit vasodilatations induced by adenosine and nitric oxide, and also that adenosine and nitric oxide can interact in a way that changes over time.”

“Both carbachol and adenosine similarly inhibited quantal release triggered by high potassium , ionomycin or sucrose.”

“It is suggested that adenosine reduces pre- and postsynaptic exicatory signals principally by enhancing one or more potassium conductances.”

“This may result from a shunting of inward current in the dendrites due to an adenosine induced increase in potassium conductance.”

“ Adenosine hyperpolarized the smooth muscle cells, by increasing potassium conductance of the membrane, with no relation to the endothelial cells.”

“ Adenosine , a potent coronary vasodilator and arresting agent, has the potential to reduce the potassium concentration required for arrest and to improve distribution of cardioplegia.”

“Cerebellar granule cells (CGCs) explanted in … apoptosis when the concentration of potassium is shifted from 25 …. We report that adenosine and ADP, which act as neurotransmitters and neuromodulators in the brain, exert in cultured cerebellar … and marked antiapoptotic action with half-maximal effect in the 10-100 microM range.”

“An elevated potassium concentration in the perfusion solution caused increases in the extracellular levels of adenosine and its metabolites, and of guanosine and the pyrimidine nucleoside uridine.”

“ Adenosine may counteract the potassium chloride-induced vasoconstriction that occurs during hyperkalemic reperfusion and may thus improve coronary flow and myocardial function.”

“ Potassium (40 mM) evoked the release of adenine nucleotides and adenosine in rat isolated caudal arteries.”