Possible Interaction: Adenosine and Potassium Chloride

“ Adenosine and its analogs (5′-N-ethyl-carboxamido-adenosine, NECA; N6-l-phenylisopropyladenosine, LPIA; 2-chloroadenosine, CAD), all inhibited the contraction induced by 25 mmol/l KCl in a concentration-dependent manner and the order of potency was found to be NECA > CAD > L-PIA > adenosine.”

“2) Tyrode's solution containing 30 mmol/L KCl (high K+ Tyrode's solution) induced [Ca2+]i elevation in ventricular myocytes, while adenosine (10, 50, 100 micromol/L) markedly inhibited the increase in [Ca2+]i induced by KCl. (”

“ Adenosine inhibits synaptosomal exocytosis of glutamate, triggered by KCl or by the K(+) channel inhibitor, 4-aminopyridine (4-AP), without affecting Ca(2+) influx.”

“ Adenosine induced a biphasic concentration-dependent decrease in KCl (35 mM) raised coronary perfusion pressure in hearts from young and mature rats, suggesting the presence of both high- and low-affinity sites for adenosine receptors in the two age groups tested.”

“Our results indicate that in cultured amacrine‐like neurons, the Ca2+‐dependent release of [3H]ACh evoked by KCl is under tonic inhibition by adenosine , which activates A1 receptors.”

“Also the interruption of fibrillation immediately after its appearance by potassium chloride decreased the release of adenosine and its metabolites in a highly significant way.”

“Contractile amplitude at 37 degrees C was significantly (P less than 0.05) greater than … degrees C. ATP (1.6 x 10(-4)-1.28 x 10(-3) M) and adenosine (… KCl (1.34 x 10(-2) M-1.07 x … high KCl (120 mM)-CaCl2-free Tyrode solution.”

“In rabbit aortic smooth muscle, adenosine inhibited the increase induced by norepinephrine (NE) in 45Ca uptake in the presence of KCl (under low affinity Ca2+ uptake conditions) and the NE-induced decrease in 45Ca uptake (under high affinity Ca2+ uptake conditions).”

“The adenosine analogs, 5'-N-ethylcarboxamidoadenosine (NECA) and 2-chloroadenosine (CAD) caused concentration-dependent relaxations of coronary rings contracted with KCl.”

“…,basal adenosine (1 microM), inosine (2 microM), hypoxanthine (4 microM), guanosine (0.5 microM) and … of each probe) were increased by the inclusion of 100 mM of KCl into the perfusion medium (2.5-, 3-, 3.5-, 1.5- …-HIAA (3 microM) levels were (72%, 68% and 45% respectively).”