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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adenosine
drug:
Physostigmine
Research Papers that Mention the Interaction
“The acetylcholine esterase inhibitor, physostigmine (7 microM), and the muscarinic receptor agonist, oxotremorine (100 microM), significantly enhanced the K(+)-evoked increase in adenosine.”
In vivo regulation of extracellular adenosine levels in the cerebral cortex by NMDA and muscarinic receptors.“The contractile responses to the nucleotides and acetylcholine, but not adenosine , were selectively potentiated by physostigmine (1 microM).”
“If injected intravenously, but immediately before physostigmine, adenosine produced a potentiation of the blood pressure response to physostigmine.”
“This was even more evident if adenosine was injected directly into the carotid artery immediately before the intravenous injection of physostigmine.”
“Contractile amplitude … potentiation by physostigmine was significantly (…) M) and adenosine (1.8 x 10(-4)-1.48 x 10(-3) M) inhibited in concentration-related fashion contractile responses induced by …) M-1.4 x 10(-5) M) and by CaCl2 in high KCl (120 mM)-CaCl2-free Tyrode solution.”
“ Physostigmine enhanced the chronotropic effects of adenosine and ATP and the dromotropic effects of ATP.”
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