Possible Interaction: Adenosine and Phenylephrine

“Methoxamine and phenylephrine also reduced the extent of accumulation of cyclic adenosine-3′,5′-monophosphate , but only when they were present at relatively high concentrations (above 100 μmol·l-1).”

“Whereas adenosine and 2-CAD effectively relaxed the tissues contracted with phenylephrine (10(-5) m).”

“ Adenosine produced a concentration-dependent relaxation in phenylephrine (2 x 10(-6) M)-contracted aortic rings and exhibited a negative chronotropic effect in the isolated perfused heart.”

“Flow increased in each layer in response to adenosine plus phenylephrine and failed to decline despite a marked reduction in perfusion pressure in response to adenosine alone.”

“4 A 1000 fold increase in the adenosine concentration was required to shift the value of the EC50 of phenylephrine six fold, while a similar increase in the value of the EC50 of adenosine could be elicited by only a 32 fold increase in the phenylephrine concentration.”

“Similarly, increasing the concentration of adenosine reduced the value of τ for phenylephrine in a concentration‐dependent and saturable manner.”

“The intracellular water space (control value 559 +/- 7 microliters/g of …; n = 88) increased on addition of insulin (35 nM) or phenylephrine (5 microM) by 12 or 8% respectively, whereas it decreased … cyclic AMP (cAMP; 50 microM), glucagon (100 nM) or adenosine (50 microM) by 9, … or 6% respectively.”

“Although adenosine significantly inhibited only the tonic phase of the contraction induced by phenylephrine (10(-5) M), it did so to both the fast and slow phases of the contraction produced by high potassium concentrations (75 mM) with no preferential difference.”

“Both adenosine and NPY dose-dependently increased the accumulation of inositol phosphates induced by phenylephrine (50 microM), but neither of the two compounds had any effect alone on inositol phosphate accumulation.”

“ Adenosine also augments the contractile response to NA and phenylephrine in the prostatic portion of the transversely bisected rat vas deferens.”

“ Adenosine failed to inhibit the positive inotropic action exerted by phenylephrine via stimulation of alpha-adrenoceptors in the presence of pindolol (30 nM).”