Possible Interaction: Adenosine and Phentolamine

“The behavior was … reduced by potent adenosine analogs, such as N6-cyclohexyl adenosine (CHA, 0.1 and 0.2 mg/kg IP) and …-(l-phenyl isopropyl) adenosine (l-PIA, 0.2 mg/kg IP), but conversely was potentiated by phentolamine (10 mg/kg IP) or … (10 mg/kg IP).”

“In AIS hearts perfused aerobically or subject to ischemia and reperfusion, phentolamine (1 microM) given in combination with adenosine , prevented adenosine-induced stimulation of glycolysis from exogenous glucose and reduced calculated proton production from glucose.”

“The detrimental switch in the metabolic and cardioprotective effects of adenosine , in hearts subject to AIS, can be prevented by phentolamine , an alpha-adrenoceptor antagonist.”

“ Adenosine (100 μM) reduced the amplitude of e.j.ps, both in the presence and in the absence of phentolamine (1 μM).”

“Theophylline and phentolamine are respective antagonists of adenosine and norepinephrine, decreased the inhibitory action by S on the contraction of guinea pig ileum about 50%.”

“In contrast, intracoronary infusions of prazosin and phentolamine during coronary hypoperfusion markedly attenuated (p less than 0.01) release of adenosine (1.8 +/- 0.7 nmol/100 g/min at 20 minutes).”

“ Phentolamine (but not propranolol) reduced the potentiated response to norepinephrine (NE) (or epinephrine) plus adenosine to the level seen with adenosine alone.”